Latos, on the disabled list since March 22 with bursitis in his right shoulder, will make his 2011 debut against a team he didn't face last season.
"It's time to get him back on the horse," Padres manager Bud Black said. "He feels ready. ... I think he's excited for his first start of the year."
Latos, who threw a side session before Friday's game against the Dodgers, told reporters this week he was itching to get into a game.
"Everything just feels right," Latos said.
Black said Latos -- who threw 70 pitches in a Minor League simulated game on Monday in Arizona -- will not be on a pitch count.
"He's pretty well stretched out," Black said.
Latos, one of three Padres pitchers to win 14 games a year ago, was on pace to make his first Opening Day start before suffering a sore shoulder two days after a March 21 exhibition start against the White Sox.