Cintron, who signed a Minor League contract with the Padres on May 3, had two hits in Tucson's game on Monday against Iowa, raising his average to .350 in 60 at-bats.
But Cintron, a career .275 hitter over parts of nine seasons for four Major League teams, decided to retire for health reasons, his agent, Burton Rocks, said by email on Tuesday. Rocks said, "[Past] surgeries have affected him physically."
Cintron, 32, was playing for Laguna of the Mexican League and was hitting .364 in five games before signing with the Padres earlier this month.
With Tucson, Cintron had 21 hits in 17 games with four doubles, one triple, one home run and six RBIs. He was not on the 40-man roster.