Kansas City dropped its other split-squad game to Cleveland, 3-2, in Goodyear, Ariz.
Ramirez cleared the right-field wall on a 2-0 pitch from left-hander Robbie Erlin with the bases empty in the fourth inning to give the Royals a 4-2 lead. In the sixth inning, he belted a three-run homer to right on a 2-2 pitch from lefty Juan Oramas.
On Monday against the Rangers, a pitch struck Ramirez in the hand, then glanced off his chin. Taken out of the game, he was diagnosed with a bruise, but otherwise unhurt and started Tuesday's game as the DH. A right-handed-hitting catcher, Ramirez is in camp as a non-roster player.
The Royals are 3-1 and the Padres are 0-3 this spring.
Right-hander Tim Stauffer, who was the Padres' Opening Day starter last year and is likely to be again in '12, worked the first two innings. He gave up one run as Jarrod Dyson, who led off with a bunt single, scored on Jeff Francoeur's sacrifice fly.
"I felt good mechanically and physically. I got a lot of ground balls," Stauffer said. "I felt a little sharper in the second inning than the first inning."
Luke Hochevar, who made his first Opening Day start last year, went two scoreless innings. He gave up one hit and one walk.
Padres third baseman-left fielder James Darnell was 2-for-2 with a double and a sacrifice fly. First baseman Kyle Blanks had two singles.
Royals up next: Left-hander Jonathan Sanchez, heralded as joining Luke Hochevar and Bruce Chen as the top three in the rotation, will be unveiled in a 2:05 p.m. CT game on Wednesday against the Cubs at Surprise Stadium. Sanchez was acquired from the Giants in exchange for outfielder Melky Cabrera. The Royals worked Sanchez in slowly during camp because he missed much of last season with biceps and ankle ailments. Another lefty, Everett Teaford, is scheduled to follow him.
Padres up next: The Padres have their first split-squad games of the spring on Wednesday. One team will remain in Peoria, Ariz., to face the Rangers at 12:05 p.m. PT. Veteran Jeff Suppan, in camp on a Minor League deal, gets the start and is scheduled to throw two innings. Pitching prospect Joe Wieland, who was obtained from the Rangers on July 31 in the Mike Adams trade, will face his former organization on the same day Yu Darvish makes his first appearance for Texas. In Goodyear, the Padres face the Reds, also at 12:05 p.m. Cory Luebke gets his first start of the spring, and pitching prospect Casey Kelly will follow him.
Dick Kaegel is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.