Gavin Floyd allowed one run over four innings with five strikeouts for the White Sox, who took a 3-1 lead into the fifth inning before the Padres started their comeback.
Floyd, the No. 3 starter in the White Sox rotation, allowed a run in the first inning and then tossed three scoreless innings. He allowed five hits and didn't walk a batter.
Trailing, 3-1, the Padres scored four runs in the fifth inning and then added one more run in the sixth inning when Matt Clark singled to center field to score Decker, who reached on his second double of the game.
Jordan Danks, Brent Lillibridge and A.J. Pierzynski each knocked in runs for the White Sox with singles. Danks and Lillibridge each had two hits.
Up next for Padres: The Padres have a split-squad day on Wednesday as one team travels to Salt River Fields in Scottsdale to face the D-backs while another heads to Goodyear to face the Reds. Prospect Joe Wieland gets the start against the D-backs and is scheduled to throw three innings. Another prospect, Casey Kelly, will pitch in Goodyear and is also set to throw three innings. Clayton Richard is also scheduled to throw three innings in that game. Wieland allowed four runs in two innings in his only appearance. Kelly tossed two shutout innings in his lone appearance.Both contests start at 1:05 p.m. PT, with Gameday Audio broadcasting the game against the Reds.