So far, Chris Denorfia, Mark Kotsay, Cameron Maybin, Andy Parrino and Will Venable have hit there as those five players have combined for a .203/.306/.671 slash line with two home runs and six RBIs.
So why Guzman, who has only one previous at-bat hitting second in his Major League career and that came last season?
"He's a good hit-and-run guy who makes good contact," Padres manager Bud Black said. "And he can hit behind the runner. Maybe it's a situation where he could get an extra at-bat."
Guzman missed the first two games of the Padres' recently completed series against the Nationals after having two teeth extracted Monday. Guzman, who entered Friday's game hitting .216, had a hit in a pinch-hitting appearance in Thursday's victory over Washington.