Maybin left Saturday's game in New York with a sprained right wrist. The injury was the result of Maybin taking extra batting practice the previous week while the team was in St. Louis.
Maybin did appear on defense in Wednesday's loss to the Cubs.
"His wrist feels ready to go," Padres manager Bud Black said. "We're excited to have Cameron back. He's confident where he is."
Maybin hit second and started in center field against the D-backs, the first game of a three-game series at Petco Park.
Maybin had five hits in consecutive games against the Cardinals and Mets on May 23-24 but went hitless in his next six at-bats. He left that game against the Mets when the pain in his wrist became unbearable.