Venable's line drive off Astros starter Jordan Lyles floated over right fielder Brian Bogusevic's head, hitting off a fan's arms and bouncing back into the field of play. Venable stopped at third base.
Padres manager Bud Black came out of the dugout to argue the call with second-base umpire and crew chief Derryl Cousins. The umpires agreed to look at the hit on video review and overturned the original decision.
Venable jogged home from third, giving the Padres a 1-0 lead.
Clark Goble is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.