Quentin missed the first two months of the season after requiring surgery to repair a tear in his meniscus in that same knee, but he has settled into the cleanup spot in the Padres order since returning from the disabled list May 28.
At one point during Monday night's game, Quentin appeared in the Padres dugout wearing a helmet and with a bat in hand, seemingly ready for a pinch-hit appearance.
While that may indicate that the injury to Quentin is not severe, the 29-year-old also will sit out Tuesday's game, according to manager Bud Black.
"I hope [he's available Tuesday]," Black said after Monday's 2-0 loss to the Astros. "I was going to give him [Tuesday] off anyway ... which I'm going to do.
"It might not be a bad idea to give him that extra day to let things quiet down."
Quentin is hitting .266 with eight home runs in 36 games this season. He was replaced in the lineup Monday by Alexi Amarista, and Mark Kotsay will get the start in left field Tuesday, according to Black.
Chelsea Janes is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.