Maybin, who hadn't started since July 17 against the Astros due to a sore right wrist, was back in center field and batting seventh for the series opener against his former team, the Marlins.
"Cam's back, he's ready to go," Padres manager Bud Black said. "He's excited to be back in there. He wants to play, and I think always coming back to one of your old teams is always a lift for players, so I think it's good for Cam to be back in the lineup tonight. He's ready, wrist is good."
Maybin has been dealing with the soreness for the last two months, but he said Friday that the wrist has been feeling better the last few days and that he hopes that it won't be an issue for the remainder of the season.
Before missing the last eight games, playing only sparingly in a limited role off the bench, Maybin was in a bit of a groove at the plate thanks to a new approach that scales back on the leg kick of his front leg. In the three games before July 18, Maybin was 7-for-12 with two doubles, two RBIs and a pair of three-hit games.
"He was feeling more comfortable, and now he's got to get that feeling back after missing some time," Black said. "But he was swinging the bat well. I hope this mini-layoff hasn't affected that. He was in a good place before. Hopefully he'll be able to pick up where he left off."
While the Padres finally got Maybin back in the lineup, Black said Alexi Amarista was available to play Friday "in all capacities" after jamming his left thumb Monday against the Giants.
"We'll see how the game plays out to see if he'll be used or not, but he's ready to go," Black said.