Quentin, who had surgery on the same knee in Spring Training, was busy during three-game weekend series at Coors Field against the Rockies, chasing fly balls, base hits and was also active on the bases.
"A lot of action in left in Colorado," Padres manager Bud Black said.
Quentin, who is hitting .265 with 15 home runs and 43 RBIs, didn't join the team until May 28, more than two months after having arthroscopic surgery.
"It's a flare-up," Black said. "You could still see him tonight in a pinch-hitting capacity."
Quentin did get a pinch-hit at-bat, lining out to center field in the top of the 11th in the Padres' 4-3 loss to the Dodgers.
Chris Denorfia got the start in left field for Quentin.