Gyorko was placed on the 15-day disabled list June 10 with a right groin strain.
"I kind of felt it when I was rounding first," Gyorko said. "I kind of pulled up a little easy, went back on the field [for defense] and could feel it a little bit, so I pulled myself out just to make sure i didn't do anything worse."
Padres manager Bud Black said there was no timetable for Gyorko's return. While Gyorko's leg tightness was some cause for concern, the rookie second baseman did not appear too concerned with the issue.
The discomfort he felt Wednesday was far less severe than the pain he experienced when he initially sustained the right groin strain in an 8-7 loss to Rockies on June 9.
"He doesn't feel anything like it did when he had the initial injury in Colorado, so that's a good thing," Black said. "His appraisal was it's not as bad as it was initially. [Team trainer Todd Hutcheson]. is going to treat it, but he didn't have anything real profound to say."
Gyorko said: "It's not nearly as bad as it was in Colorado, so I guess, if anything, it's good. It doesn't seem as bad."
Logan Forsythe has been solid in Gyorko's absence, compiling a .274 batting average, eight runs scored and nine RBIs in 16 games before Friday. But Black was concerned with the setback sustained by one of the best bats in his lineup.
Despite missing 16 games in June, Gyorko ranked second on the team with 36 runs scored, tied for second with eight home runs and second in batting average (.284) among Padres with at least 150 at-bats through Thursday.
"That was a little bit discouraging that he reinjured it a little bit," Black said.
Before experiencing the tightness, Gyorko felt confident he would return soon. The second baseman said he felt "great" before experiencing the leg tightness.
"I ran full speed at home before I left," Gyorko said. "I ran the bases 100 percent. It felt great in [batting practice]. It felt great catching ground balls before the game. Obviously, I wasn't expecting it to do anything."