But Renteria's second challenge in the top of the fifth went against the Cubs.
Replay confirmed first-base umpire Phil Cuzzi's call that Padres starting pitcher Tim Stauffer tagged the bag at first ahead of Emilio Bonifacio on the center fielder's grounder to the right side. Stauffer caught a toss from first baseman Yonder Alonso as his foot hit the bag.
Renteria is 10-9 on replay challenges this season.
Bill Center is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.