Grandal was called for catcher's interference after the bat struck his left hand. He doubled over in pain before leaving with trainer Todd Hutcheson.
San Diego manager Bud Black said after the game that Grandal had an X-ray on the hand that proved to be negative.
"That's a good thing," Black said. "He's going to be sore. We'll keep an eye on him [Wednesday]."
The Padres replaced Grandal with the only other catcher on their roster, Rene Rivera.
Rivera will start Wednesday and the team is off Thursday. The Padres are hoping Grandal will be ready when the team starts a three-game series Friday in Chicago against the White Sox.
That's certainly a far better scenario than the one Grandal was pondering right after Goldschmidt hit his hand.
"I was expecting them [training staff] to tell me I had a broken pinkie and a fractured knuckle," Grandal said.
Grandal, the team's primary catcher, entered the game hitting .200 with five home runs and 15 RBIs.