"We have concerns about him. He's having difficulty responding to the throwing program between games," said Padres assistant general manager A.J. Hinch. "He's not comfortable throwing. We do have concerns that he hasn't responded well. He's having difficulty throwing."
Fried was the seventh-overall Draft pick in 2012 out of Harvard-Westlake High School in Los Angeles and is widely considered the top pitching prospect in the entire organization.
That appearance on July 21 was only the second for Fried for Fort Wayne after starting his 2014 season late because of being on a delayed program, the result of soreness in his left forearm that he first felt in February when he reported for prospect minicamp in Arizona.
Fried appeared in two games in the Arizona League earlier this month before heading to Fort Wayne, where he pitched 3 2/3 innings on July 16 and then two innings on Monday.
Fried would have started this season with Class A Advanced Lake Elsinore of the California League had he been healthy.
He spent all of last season pitching in Fort Wayne, going 6-7 with a 3.49 ERA in 118 2/3 innings, allowing 107 hits with 100 strikeouts.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.